Reactions of 4-hydroxycoumarin with heterocyclic aldehydes
DOI:
https://doi.org/10.36547/nbc.1146Keywords:
coumarin, 4-oxo-4H-chromene, furan, furo[3,2-b]pyrrole, microwaveAbstract
Reactions of 4-hydroxycoumarin 1 with heterocyclic aldehydes 2-4 led to bis-4-hydroxycoumarin derivatives 5-7 under microwave irradiation as well as under the classical heating. The subsequent reactions of products 5-7 are described. 4,4’-Epoxydicoumarins 8, 9 were prepared by the reaction of 5-7 in acetic acid / p-toluenesulfonic acid medium. Compound 10 was prepared by the reaction of 5 in acetic anhydride in the presence sodium acetate. Dioxocine-1,15-dione 11 was prepared by the reaction of 6 with dichloromethane in sodium hydroxide-toluene.Downloads
Published
2021-09-02
How to Cite
Gašparová, R., Kotlebová, K., & Lácová, M. (2021). Reactions of 4-hydroxycoumarin with heterocyclic aldehydes. Nova Biotechnologica Et Chimica, 9(3), 349–354. https://doi.org/10.36547/nbc.1146
Issue
Section
Research Articles
License
Copyright (c) 2021 Renáta Gašparová, Katarína Kotlebová, Margita Lácová
This work is licensed under a Creative Commons Attribution 4.0 International License.
All papers published in the Nova Biotechnologica et Chimica (NBC) are published under a CC-BY licence (CC-BY 4.0). Published materials can be shared (copy and redistribute the material in any medium or format) and adapted (remix, transform, and build upon the material for any purpose, even commercially) with specifying the author(s).