Reactions of 4-hydroxycoumarin with heterocyclic aldehydes
Keywords:coumarin, 4-oxo-4H-chromene, furan, furo[3,2-b]pyrrole, microwave
AbstractReactions of 4-hydroxycoumarin 1 with heterocyclic aldehydes 2-4 led to bis-4-hydroxycoumarin derivatives 5-7 under microwave irradiation as well as under the classical heating. The subsequent reactions of products 5-7 are described. 4,4’-Epoxydicoumarins 8, 9 were prepared by the reaction of 5-7 in acetic acid / p-toluenesulfonic acid medium. Compound 10 was prepared by the reaction of 5 in acetic anhydride in the presence sodium acetate. Dioxocine-1,15-dione 11 was prepared by the reaction of 6 with dichloromethane in sodium hydroxide-toluene.
How to Cite
Gašparová, R., Kotlebová, K., & Lácová, M. (2021). Reactions of 4-hydroxycoumarin with heterocyclic aldehydes. Nova Biotechnologica Et Chimica, 9(3), 349-354. https://doi.org/10.36547/nbc.1146
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