Reactions of 4-hydroxycoumarin with heterocyclic aldehydes

Authors

  • Renáta Gašparová Department of Chemistry, University of SS. Cyril and Methodius, J. Herdu 2, Trnava, SK-917 01, Slovak Republic
  • Katarína Kotlebová Department of Chemistry, University of SS. Cyril and Methodius, J. Herdu 2, Trnava, SK-917 01, Slovak Republic
  • Margita Lácová Department of Organic Chemistry, Comenius University, Mlynská dolina CH-2, Bratislava, SK-842 15, Slovak Republic

DOI:

https://doi.org/10.36547/nbc.1146

Keywords:

coumarin, 4-oxo-4H-chromene, furan, furo[3,2-b]pyrrole, microwave

Abstract

Reactions of 4-hydroxycoumarin 1 with heterocyclic aldehydes 2-4 led to bis-4-hydroxycoumarin derivatives 5-7 under microwave irradiation as well as under the classical heating. The subsequent reactions of products 5-7 are described. 4,4’-Epoxydicoumarins 8, 9 were prepared by the reaction of 5-7 in acetic acid / p-toluenesulfonic acid medium. Compound 10 was prepared by the reaction of 5 in acetic anhydride in the presence sodium acetate. Dioxocine-1,15-dione 11 was prepared by the reaction of 6 with dichloromethane in sodium hydroxide-toluene.

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Published

2021-09-02

How to Cite

Gašparová, R., Kotlebová, K., & Lácová, M. (2021). Reactions of 4-hydroxycoumarin with heterocyclic aldehydes. Nova Biotechnologica Et Chimica, 9(3), 349-354. https://doi.org/10.36547/nbc.1146

Issue

Section

Research Articles
Received 2021-09-02
Published 2021-09-02