Control of magnetic susceptibility of probiotic strain Lactobacillus rhamnosus GG

Authors

  • Svitlana Gorobets Faculty of Biotechnology and Biotechnics, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, 03056 Kyiv, Ukraine
  • Oksana Gorobets Faculty of Physics and Mathematics, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, 03056 Kyiv, Ukraine
  • Liubov Kuzminykh Faculty of Biotechnology and Biotechnics, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, 03056 Kyiv, Ukraine

DOI:

https://doi.org/10.34135/nbc.1384

Keywords:

Lactobacillus rhamnosus GG, Iron chelate, Magnetically-guided vector, Magnetic susceptibility, Targeted drug delivery, Permanent magnetic field

Abstract

The paper investigates the increase in the natural magnetically controlled properties of probiotic microorganisms Lactobacillus rhamnosus GG (LGG) and their ability to form magnetically sensitive inclusions (MsI). The magnetic susceptibility of LGG was increased by modifying the nutrient medium composition and by cultivating the probiotic culture in a constant magnetic field. Therefore, this study can be useful for their further use as magnetically controlled vectors since it is being extensively researched for their use in targeted drug delivery in cancer treatment, for the prevention of chemotherapy complications, etc. The results of this study indicate that growing microorganisms with natural magnetically-guided properties in a modified medium with iron chelate and in an external magnetic field leads to an increase in the magnetic susceptibility of LGG by 1.8 and 2.6 times, respectively, compared with the control. The best magnetic susceptibility was recorded for LGG suspensions, which were grown in a constant magnetic field and cultured in modified medium with iron chelate. The LGG suspension, grown both in a constant magnetic field and on a modified medium with iron chelate, had the highest magnetic susceptibility, and it was 4.8 times larger than the magnetic susceptibility in the control.

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Published

2023-07-21

How to Cite

Gorobets, S., Gorobets, O., & Kuzminykh, L. (2023). Control of magnetic susceptibility of probiotic strain Lactobacillus rhamnosus GG. Nova Biotechnologica Et Chimica, 22(1), e1384. https://doi.org/10.34135/nbc.1384

Issue

Vol. 22 No. 1 (2023)

Section

Research Articles

License

Copyright (c) 2023 Svitlana Gorobets, Oksana Gorobets, Liubov Kuzminykh

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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