Effects of dihydroquercetin, 1-aryltetrahydroisoquinoline, and conjugate on the functional condition mitochondrial membrane of the rat liver

Authors

  • Zafarjon Ernazarov Institute of Biophysics and Biochemistry at the National University of Uzbekistan named after Mirzo Ulugbek, Almazar district, Student town, 174, Tashkent 100174, Uzbekistan
  • Mamurjon K. Pozilov National University of Uzbekistan named after Mirzo Ulugbek, University str. 4, Tashkent 100174, Uzbekistan
  • Muzaffar I. Asrarov Institute of Biophysics and Biochemistry at the National University of Uzbekistan named after Mirzo Ulugbek, Almazar district, Student town, 174, Tashkent 100174, Uzbekistan
  • Sherzod N. Zhurakulov National University of Uzbekistan named after Mirzo Ulugbek, University str. 4, Tashkent 100174, Uzbekistan and Acad. S. Yunusov Institute of the Chemistry of Plant Substances Academy of Sciences of Uzbekistan, M. Ulugbek st. 77, Tashkent 100170, Uzbekistan

DOI:

https://doi.org/10.34135/nbc.1414

Keywords:

DHQ-11 conjugate, F-18 isoquinoline alkaloid, Fe2 /citrate, Lipid peroxidation, Mitochondria

Abstract

Abstract

In the current research paper, the flavonoid dihydroquercetin, 1-(2´-bromine-4´,5´-dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) and 2-(3,4-dihydroxyphenyl)-6-(1-(2´-bromine-4´, 5´-dimethoxyphenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2 (1N)-il) methyl-3. The effects of 5,7-trigidroxychroman-4-on (DHQ-11) conjugate on rat liver mitochondrial calcium megachannels and on lipid peroxidation (LPO) induced using Fe2+/citrate were investigated in vitro experiments. White male rats weighing 180-200 grams were used in the experiments. It was found that the DHQ-11 conjugate was identified to have an inhibitory effect on rat liver mitochondria to calcium megachannels and peroxidation of lipids induced by Fe2+/citrate. The inhibitory properties of DHQ-11 conjugate on hepatic mitochondrial calcium megachannels and mitochondrial membrane lipid peroxidation were identified as active against dihydroquercetin and the F-18 isoquinoline alkaloid.

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Published

2023-07-21

How to Cite

Ernazarov, Z., Pozilov, M. K., Asrarov, M. I., & Zhurakulov , S. N. (2023). Effects of dihydroquercetin, 1-aryltetrahydroisoquinoline, and conjugate on the functional condition mitochondrial membrane of the rat liver. Nova Biotechnologica Et Chimica, 22(1), e1414. https://doi.org/10.34135/nbc.1414

Issue

Vol. 22 No. 1 (2023)

Section

Research Articles

License

Copyright (c) 2023 Zafarjon M. Ernazarov, Mamurjon K. Pozilov, Muzaffar I. Asrarov, Sherzod N. Zhurakulov

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