The Effects of Combinatorial Chemistry and Technologies on Drug Discovery and Biotechnology – a Mini Review

Authors

  • PIERFAUSTO SENECI
  • GIORGIO FASSINA
  • VLADIMIR FRECER
  • STANISLAV MIERTUS

DOI:

https://doi.org/10.1515/nbec-2015-0001

Keywords:

combinatorial chemistry, combinatorial technologies, compound libraries, computer-assisted combinatorial drug design, virtual screening, display libraries, chemical tools, chemical biology, target identification, fragment-based drug design, combinatorial proteomics

Abstract

The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial chemistry/high throughput synthesis in medicinal chemistry; the rational design of combinatorial libraries using computer-assisted combinatorial drug design; and the use of combinatorial technologies in biotechnology. The impact of “combinatorial thinking” in drug discovery in general, and in the examples reported in details, is critically discussed. Finally, an expert opinion on current and future trends in combinatorial chemistry and combinatorial technologies is provided.

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Published

2014-12-31

How to Cite

SENECI, P., FASSINA, . G. ., FRECER, V. ., & MIERTUS, S. . (2014). The Effects of Combinatorial Chemistry and Technologies on Drug Discovery and Biotechnology – a Mini Review. Nova Biotechnologica Et Chimica, 13(2), 87–108. https://doi.org/10.1515/nbec-2015-0001

Issue

Section

Reviews
Received 2020-01-16
Published 2014-12-31