@article{Grigorakis_Halahlah_Makris_2020, title={Stability of Salvia fruticosa Mill. polyphenols and antioxidant activity in a citrate-based natural deep eutectic solvent}, volume={19}, url={https://journals.scicell.org/index.php/NBC/article/view/775}, DOI={10.36547/nbc.v19i2.775}, abstractNote={<p>In a previous study, it was demonstrated that a novel deep eutectic solvent (DES), composed of lactic acid and sodium citrate dibasic at a molar ratio of 15:1 (LA-SCDB15), was a high-performing system with regard to polyphenol extraction from the medicinal plant <em>Salvia fruticosa</em> Mill. (Greek or Cretan sage). However, an issue of particular importance that should be addressed is the stability of the extract in this novel liquid since the information available to-date on extract stability in DES is rather limited and inconclusive. In this frame, this study was undertaken to generate extracts of <em>S. fruticosa</em> with LA-SCDB15 (a 77/23 w/w mixture of DES with water) and examine their stability in this solvent. <em>S. fruticosa</em> extracts exhibited remarkable stability under both accelerated and long-term conditions, and the antiradical activity and the ferric-reducing power of the extracts were shown to suffer virtually trivial modifications. Further analytical examination with liquid chromatography-diode array-tandem mass spectrometry assured that the major polyphenolic phytochemicals occurring in <em>Salvia fruticosa </em>extracts underwent non-significant changes and remained practically intact. It was concluded that the neoteric DES LA-SCDB15 may provide outstanding stability in polyphenol-containing extracts and its testing on other plant extracts is proposed as a further step towards revealing its stabilizing potential.</p>}, number={2}, journal={Nova Biotechnologica et Chimica}, author={Grigorakis, Spyros and Halahlah, Abedalghani and Makris, Dmitris}, year={2020}, month={Dec.}, pages={200–207} }