Applications substituted 2-aminothiophenes in drug design

Authors

  • Zita Puterová Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, Bratislava, SK-832 3, Slovak Republic
  • Alžbeta Krutošíková Department of Chemistry, University of SS. Cyril and Methodius, J. Herdu 2, Trnava, SK-917 01, Slovak Republic
  • Daniel Végh Institute of Organic Chemistry, Catalysis and Petrochemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9,Bratislava, SK-812 37, Slovak Republic

DOI:

https://doi.org/10.36547/nbc.1274

Keywords:

substituted 2-aminothiophenes, Gewald reaction, thieno[2,3-d][1,3]oxazin-4-ones, allosteric enhancers, 3-deazathiadiamine, drug design

Abstract

Highly substituted thiophene derivatives are important heterocycles found in numerous biologically active compounds. Title compounds are attractive derivatives because their applications in pharmaceuticals, agriculture and pesticides. They exhibit antimicrobial activity against various Gram(+) and Gram(-) bacteria and fungi. Many of these molecules act as allosteric enhancers of A1-adenosine receptor, glucagon antagonists as well as antioxidant and anti-inflammatory agents.

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Published

2021-11-22

How to Cite

Puterová, Z., Krutošíková, A., & Végh, D. (2021). Applications substituted 2-aminothiophenes in drug design. Nova Biotechnologica Et Chimica, 9(2), 167-173. https://doi.org/10.36547/nbc.1274

Issue

Section

Research Articles
Received 2021-11-22
Published 2021-11-22