Study of anaesthetical activity of alkoxyphenylcarbamic acid esters using statistical methods

Authors

  • Tatiana Ďurčeková Department of Chemistry, University of SS. Cyril and Methodius, J. Herdu 2, Trnava, SK-917 01, Slovak Republic
  • Ján Mocák Department of Chemistry, University of SS. Cyril and Methodius, J. Herdu 2, Trnava, SK-917 01, Slovak Republic, Institute of Analytical Chemistry, Slovak University of Technology, Radlinskeho 9, SK-81237 Bratislava, Slovak Republic
  • Jozef Lehotay Department of Biotechnology, University of SS. Cyril and Methodius, SK-917 01 Trnava, Slovak Republic, Institute of Analytical Chemistry, Slovak University of Technology, Radlinskeho 9, SK-81237 Bratislava, Slovak Republic
  • Jozef Čižmárik Department of Pharmaceutical Chemistry, Comenius University, Odbojarov 10, SK-83232 Bratislava, Slovak Republic

DOI:

https://doi.org/10.36547/nbc.1368

Keywords:

alkoxyphenylcarbamic acid esters, anaesthetical activity, correlation analysis, cluster analysis, principal component analysis

Abstract

Anaesthetical activity of 113 morpholinoethyl-, piperidinoethyl-, piperidinopropyl- and azepanoethyl- ester derivatives of alkoxyphenylcarbamic acid was characterized by several chemometrical techniques. The surface anaesthetical activity, A, and the infiltration anaesthetical activity, B, were correlated to lipophilicity, (expressed by the logarithm of the HPLC retention factor, log k), the length of the side alkoxy chain (represented by the number n of carbon atoms), molar mass M as well as the ester type. Principal component analysis and cluster analysis were used for predicting both types of the anaesthetic activity of the alkoxyphenylcarbamic acid esters.

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Published

2022-01-13

How to Cite

Ďurčeková, T., Mocák, J., Lehotay, J., & Čižmárik, J. (2022). Study of anaesthetical activity of alkoxyphenylcarbamic acid esters using statistical methods. Nova Biotechnologica Et Chimica, 7(1), 123–128. https://doi.org/10.36547/nbc.1368

Issue

Vol. 7 No. 1 (2007)

Section

Research Articles

License

Copyright (c) 2022 Tatiana Ďurčeková, Ján Mocák, Jozef Lehotay, Jozef Čižmárik

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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