Avenanthramides as nutraceuticals, their physical-chemical-biological properties, and possibilities of their determination (Mini-review)

Authors

  • Patrik Beňovič Faculty of Healthcare, Alexander Dubček University of Trenčín, Študentská 2, 911 50 Trenčín, Slovakia
  • Andrea Purdešová Department of Chemistry, Institute of Chemistry and Environmental Science, Faculty of Natural Sciences, University of Ss. Cyril and Methodius in Trnava, Nám. J. Herdu 2, 917 01 Trnava, Slovakia
  • Anna Jurčová

DOI:

https://doi.org/10.34135/nbc.2029

Keywords:

Biological effect, Physicochemical properties, Methods of determination

Abstract

Oats are considered a nutraceutical due to the content of biologically significant substances such as, among other substances contained in oats, avenanthramides, the most important of which are avenanthramides A, B and C. These substances in terms of their physical and chemical properties meet Lipinski's criteria, which means that we can consider these substances as potentially pharmaceuticals. They could find their application due to their antioxidant, antitumor, anti-inflammatory, anti-obesity, vasodilating, and anti-diabetic effect, in the therapy of several diseases. Extraction of avenanthramides from oats for analytical purposes is most effectively done using 70% methanol, while for commercial purposes, utilizing CO2 in a supercritical state is preferred. Analyzes of avenanthramides are mainly carried out by means of RP-HPLC with a UV/DAD detector, while currently there is a growing trend of determining avenanthramides by means of HPLC with MS for the unambiguous identification of avenanthramides and to reduce the LOQ.

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Published

2024-12-29

How to Cite

Beňovič, P., Purdešová, A., & Jurčová, A. (2024). Avenanthramides as nutraceuticals, their physical-chemical-biological properties, and possibilities of their determination (Mini-review). Nova Biotechnologica Et Chimica, 23(3), e2029. https://doi.org/10.34135/nbc.2029

Issue

Vol. 23 No. 3 (2024)

Section

Reviews

License

Copyright (c) 2024 Patrik Beňovič, Andrea Purdešová, Anna Jurčová

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