SYNTHESIS AND REACTIONS OF NEW DERIVATIVES OF FURO[3,2-b]PYRROLE

Authors

  • IVANA ZEMANOVÁ
  • RENATA GAŠPAROVÁ

DOI:

https://doi.org/10.2478/nbec-2013-0012

Keywords:

aldoxime, carbohydrazide, furo[3,2-b]pyrrole, microwave irradiation, hippuric acid

Abstract

Synthesis of methyl 4H-furo[3,2-b]pyrrole-5-carboxylate is taken place in two step synthesis. Vilsmeier-Haack reaction of 4H-furo[3,2-b]pyrrole-5-carboxylate 1 led to methyl 2-formyl-4H-furo[3,2- b]pyrrole-5-carboxylate 4, which served as starting compound for synthesis of furo[3,2-b]pyrrole-2- aldoxime 5 and methyl 2-[(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-4H-furo[3,2-b]pyrrole-5- carboxylate 7. The hydrazinolysis of 1 was prepared by carbohydrazide 2, which subsequently reacted with aldehydes to form of derivatives 3. Pyrazole derivatives 11 were prepared by the reaction of azlactone 9 with derivatives 10. Reactions were carried out under microwave irradiation or at classical heating.

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How to Cite

ZEMANOVÁ, I. ., & GAŠPAROVÁ, R. . (2013). SYNTHESIS AND REACTIONS OF NEW DERIVATIVES OF FURO[3,2-b]PYRROLE. Nova Biotechnologica Et Chimica, 12(2), 100–107. https://doi.org/10.2478/nbec-2013-0012

Issue

Section

Research Articles
Received 2020-01-16