Interplay Between Bacteriophages and Restriction-Modification Systems in Enterococci

Authors

  • PETER PRISTAS
  • ANNA VANDZUROVA
  • PETER JAVORSKY

DOI:

https://doi.org/10.2478/nbec-2014-0002

Keywords:

Enterococcus, bacteriophage, restriction modification systems, palindrome avoidance

Abstract

The complete genomes of Enterococcus faecalis bacteriophages were analyzed for tetranucleotide words avoidance. Very similar tetranucleotide composition was found in all tested genomes with strong underrepresentation of palindromic GATC and GGCC words. This avoidance could be explained as a protection mechanism against host restriction-modification systems as a clear correlation was found between avoidance of palindromic words and the specificity of E. faecalis restriction and modification systems. No similar avoidance of tetranucleotide words was observed for non-palindromic words. A weak correlation was observed between avoidance of tetranucleotide palindromes in bacteriophage genomes and the possession of phage encoded DNA methyltransferases confirming the interrelation between bacteriophage genomes composition and restriction and modification systems in enterococci.

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How to Cite

PRISTAS, P. ., VANDZUROVA, A. ., & JAVORSKY, P. . (2014). Interplay Between Bacteriophages and Restriction-Modification Systems in Enterococci. Nova Biotechnologica Et Chimica, 13(1), 13–20. https://doi.org/10.2478/nbec-2014-0002

Issue

Vol. 13 No. 1 (2014)

Section

Research Articles

License

All papers published in the Nova Biotechnologica et Chimica (NBC)  are published under a CC-BY licence (CC-BY 4.0). Published materials can be shared (copy and redistribute the material in any medium or format) and adapted (remix, transform, and build upon the material for any purpose, even commercially) with specifying the author(s).