A New Approach to Identification of Biomarkers for Early Cancer Stage Detection

Authors

  • BOGUSŁAW BUSZEWSKI
  • JOANNA RUDNICKA
  • MARTA WALCZAK
  • TADEUSZ JEZIERSKI

DOI:

https://doi.org/10.2478/nbec-2014-0003

Keywords:

volatile organic compounds, breath analysis, gas chromatography-mass spectrometry, canine olfaction

Abstract

Gas chromatography and mass spectrometry (GC/MS) was applied for determination of concentrations volatile organic compounds present in human breath samples. The technique allows to rapid determination compounds in human air, at the level of parts per billion. It showed linear correlations ranging from 0.83-234.05 ppb, limit detection in the range of 0.31-0.75 ppb and precision, expressed as RSD, was less then 10.00%. Moreover, trained dogs are able to discriminate breath samples of patients with diagnosed cancer disease. We found positive correlation between dog indications and content of ethyl acetate and 2- pentanone in breath (r=0.85 and r=0.97, respectively).

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How to Cite

BUSZEWSKI, B. ., RUDNICKA, J. ., WALCZAK, M. ., & JEZIERSKI, T. (2014). A New Approach to Identification of Biomarkers for Early Cancer Stage Detection. Nova Biotechnologica Et Chimica, 13(1), 21–27. https://doi.org/10.2478/nbec-2014-0003

Issue

Vol. 13 No. 1 (2014)

Section

Research Articles

License

All papers published in the Nova Biotechnologica et Chimica (NBC)  are published under a CC-BY licence (CC-BY 4.0). Published materials can be shared (copy and redistribute the material in any medium or format) and adapted (remix, transform, and build upon the material for any purpose, even commercially) with specifying the author(s).