Synthesis of 4-OXO-4H-Chromene Derivative with Fused Benzodiazepine Ring

Authors

  • IVANA ZEMANOVÁ
  • MICHAELA POTANČOKOVÁ
  • RENATA GAŠPAROVÁ

DOI:

https://doi.org/10.1515/nbec-2016-0009

Keywords:

4-oxo-4H-chromene, 1,2-diaminobenzene, diazepine, fused heterocycles

Abstract

6-Acetylbenzo[b]chromeno[2,3-e][1,4]diazepin-13(6H)-one 6 was synthesized by reaction of 4- oxo-4H-chromene-3-carboxaldehyde 1 with 1,2-diaminobenzene 2 followed by cyclisation of formed Schiff base 3 and spontaneous oxidation of dihydrodiazepine 4 by air oxygen. Finally, diazepine 5 was acetylated at N(6) by reaction with acetic anhydride.

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How to Cite

ZEMANOVÁ, I. ., POTANČOKOVÁ, M. ., & GAŠPAROVÁ, R. . (2016). Synthesis of 4-OXO-4H-Chromene Derivative with Fused Benzodiazepine Ring. Nova Biotechnologica Et Chimica, 15(1), 85–89. https://doi.org/10.1515/nbec-2016-0009

Issue

Vol. 15 No. 1 (2016)

Section

Research Articles

License

All papers published in the Nova Biotechnologica et Chimica (NBC)  are published under a CC-BY licence (CC-BY 4.0). Published materials can be shared (copy and redistribute the material in any medium or format) and adapted (remix, transform, and build upon the material for any purpose, even commercially) with specifying the author(s).