Biosafety of genetically modified wheat (Triticum aestivum) Hi-line 111


  • Mohamed Abd-Elfattah Mohamed Hassan
  • Rafaat Mohamed Elsanhoty
  • Mohamed Fawzy Ramadan
  • Mohyeldeen Ali Osman



Genetic modification, GMO, Histopathology rats, Safety assessment, Serum biochemistry, Transgenic wheat


Genetically modified (GM) crops were approved for edible use in several countries but their biosafety for organisms remains to be crucial. The objectives of this work were to compare GM wheat (Triticum aestivum) Hi-line 111 (GMW) with native non-GMW wheat (NGMW) to find the differences, if any, in their biosafety. Three groups of albino rats (Rattus norvegicus) were used to study the biosafety of GMW for 30 days. Group 1 was fed on a basal diet (control), and group 2 on a control diet with 30% replacement of starch with NGMW, while group 3 was fed on the control diet with 30% replacement of starch with GMW. There were no significant signs of adverse impacts noted in the clinical appearance of animals fed on GMW in terms of initial body weight, absolute or relative organ weights and serum profile in comparison with the control group. However, slight histopathological changes were observed in the organs of animals fed on GMW. Though our results demonstrate GMW biosafety regarding its biochemical parameters, however, detailed description of submucosal edema and further studies on allergenic potential with long feeding periods should be performed to conclude its impacts on health.

Author Biographies

Mohamed Abd-Elfattah Mohamed Hassan

Food Technology Research Institute, Agriculture Research Center, 9 ALgamaa Street, Giza, Egypt

Rafaat Mohamed Elsanhoty

Department of Industrial Biotechnology, Institute of Genetic Engineering and Biotechnology, Sadat City University, Egypt

Mohamed Fawzy Ramadan

Department of Agricultural Biochemistry, Faculty of Agriculture, Zagazig University, Zagazig 44519, Egypt.

Deanship of Scientific Research, Umm Al-Qura University, Makkah, Saudi Arabia.

Mohyeldeen Ali Osman

Department of Biochemistry, Faculty of Agriculture, Cairo University, Egypt




How to Cite

Hassan, M. A.-E. M. ., Elsanhoty, R. M. ., Ramadan, M. F. ., & Osman, M. A. . (2020). Biosafety of genetically modified wheat (Triticum aestivum) Hi-line 111. Nova Biotechnologica Et Chimica, 19(1), 19–29.



Research Articles