Effect of diterpene alkaloids on lipid peroxidation in mitochondria

Authors

  • Dilnoza Kh. Muratova Institute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Almazar district, Student town 174, Tashkent 100174, Uzbekistan
  • Nurali A. Ergashev Institute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Almazar district, Student town 174, Tashkent 100174, Uzbekistan
  • Jobir J. Sobirov Tashkent State Agrarian University, Tashkent region, Kibray district, Universitet street 2-house, Tashkent 100140, Uzbekistan
  • Utkir Kh. Kurbanov Acad. S. Yunusov Institute of the Chemistry of Plant Substances Academy of Sciences of Uzbekistan, M. Ulugbek street 77, Tashkent 100170, Uzbekistan
  • Muzaffar I. Asrarov Institute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Almazar district, Student town 174, Tashkent 100174, Uzbekistan

DOI:

https://doi.org/10.36547/nbc.850

Keywords:

alkaloids, Fe2 /ascorbate, lipid peroxidation, malondialdehyde, mitochondria

Abstract

In this article, the antioxidant activity of some alkaloids lipid peroxidation (LPO) in rat liver mitochondria has been studied. It has been established that diterpenoid alkaloids: 1-О-benzoylnapelline, napelline and songorine have a protective effect on mitochondria, reducing the damaging effect of Fe2+/ascorbate and the release of malondialdehyde (MDA) into the secondary products of peroxidation. The effect of alkaloids napelline, 1-O-benzoylnapelline and songorine on the processes of MDA formation in rat liver mitochondria in vitro has been studied.Where in at 200 мM concentrations, 1-О-benzoylnapelline inhibited the formation of MDA by 95 %, and the alkaloids napelline and songorine at this concentration inhibited the formation of MDA by 54 and 44 %. From the data obtained, it can be shown that 1-О-benzoylnapelline strongly inhibits the formation of MDA compared to songorine and napelline.

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Published

2021-11-30

How to Cite

Muratova, D. K., Ergashev, N. A., Sobirov, J. J., Kurbanov, U. K., & Asrarov, M. I. (2021). Effect of diterpene alkaloids on lipid peroxidation in mitochondria. Nova Biotechnologica Et Chimica, 20(2), e850. https://doi.org/10.36547/nbc.850

Issue

Section

Research Articles
Received 2021-03-09
Accepted 2021-06-28
Published 2021-11-30